孙金玉副教授，硕士生导师

E-mail：jysun15@163.com

地址：河北省石家庄市裕华区南二环20号银河集团官网，050024

本课题组每年招收有机化学、药学硕士研究生，欢迎联系。

研究领域

课题组致力于以化学合成分子为工具，开展生物医学相关标志物的标记与成像研究，长期聚焦基于发光成像技术（包括荧光、生物/化学发光及核素成像）的生物分子检测方法开发。课题组负责人已在Chemical Science、Analytical Chemistry、ACS Sensors、Sensors & Actuators: B. Chemical、Chemical Communication、Analyst等国际知名期刊发表SCI论文20余篇，并长期担任Analytical Chemistry、ACS Sensors、Bioconjugate Chemistry等高水平期刊的审稿人。目前担任《精细化工》青年编委及中国中医药信息学会临床智慧医疗分会理事。当前研究兴趣主要包括：1. 细胞内生物/化学发光成像；2. 活细胞内RNA成像标签的构建；3. 新型成像染料的设计与应用研究；4. 核素治疗成像。

教育及工作背景

2011.09-2016.06  兰州大学有机化学，博士

2016.08-2019.04 清华大学化学系，博士后

2019.06-2024.12  西北工业大学医学研究院，副教授

2025.08-至今 银河集团官网，副教授

主持项目

1. 银河welcome娱乐网站启动基金，在研。

2. 陕西省重点研发社发项目（2025SF-YBXM-285），主持，在研。

3. 银河welcome娱乐网站晏梁学术智库专项，主持，在研。

4. 企业委托，化学发光底物分子的合成，主持，在研。

5. 企业委托，贵金属催化异味有机小分子分解，主持，在研。

6. 国家自然科学基金青年项目（22204127）， 主持，结题。

7. 深圳市科技计划基础研究-面上项目（31020190QD00），主持，结题。

8. 广东省基础与应用基础研究基金（2021A151511090），主持，结题。

9. 陕西省科学技术厅（2022JQ-106），主持，结题。

文章发表

1. Liya Ai, Yingzhuang Song, Shudi Liu, Zhijing Xu, Jinyu Sun*. A novel bioluminescent probe for detecting newly synthesized phosphatidylcholine. (Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2025,126485)

2. Zhijing Xu, Yingzhuang Song, Jinyu Sun*. Simultaneous production of singlet oxygen and superoxide anion by thiocarbonyl coumarin for photodynamic therapy. (Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2024,125327)

3. Yingzhuang Song, Zhijing Xu and Jinyu Sun*. Metabolic labeling and bioluminescent imaging of nascent peptidoglycan. (Sensors & Actuators: B. Chemical,2022)

4. Jinyu Sun, Zhian Hu, Sichun Zhang, Xinrong Zhang*. A highly sensitive chemiluminescent probe for detecting nitroreductase and imaging in living animal. (Analytical Chemistry, 2019, 91, 1384-1390）

5. Jinyu Sun, Zhian Hu, Sichun Zhang, Xinrong Zhang*. A novel chemiluminescent probe based on 1,2-dioxetane scaffold for imaging cysteine in living mice.  (ACS Sensors, 2019, 4, 87-92 ）

6. Jinyu Sun, Liangwei Zhang, Yuesong Hu, Jianguo Fang*. Highly selective fluorometric probes for detection of HClO in living cells. (Sensors & Actuators: B. Chemical, 2018, 447-454)

7. Jinyu Sun, Liangwei Zhang, Shoujiao Peng, Xiaolong Zhang, Yuesong Hu, Jianguo Fang*. An ultrafast turn-on thiol probe for protein labeling and bioimaging. (Analyst, 2016, 2009-2015)

8. Liangwei Zhang, Shoujiao Peng, Jinyu Sun, Juan Yao, Jie Kang, Yuesong Hu and Jianguo Fang*. A specific fluorescent probe reveals compromised activity of methionine sulfoxide reductases in Parkinson's disease. (Chemical Science, 2017, 8, 2966-2972).

9. Liangwei Zhang, Shoujiao Peng, Jinyu Sun, Ruijuan Liu, Shudi Liu and Jianguo Fang*. A ratiometric fluorescent probe of methionine sulfoxide reductase with an improved response rate and emission wavelength. (Chemical Communication, 2019, 55, 1502-1505).

10. Yuesong Hu, Jie Kang, Panpan Zhou, Xiao Han, Jinyu Sun, Shudi Liu, Liangwei Zhang*, Jianguo Fang*. A selective colorimetric and red-emitting fluorometric probe for sequential detection of Cu2+ and H2S. (Sensors & Actuators: B. Chemical，255, 3155-3162).

11. Liangwei Zhang, Jinyu Sun, Shudi Liu, Xuemei Cui, Weishuang Li, Jianguo Fang*, Aminoquinoline-based fluorescent probe for detection of Cu2+ and hydrogen sulfide. (Inorganic Chemistry Communications, 2013, 35, 311-314).

12. Liangwei Zhang, Xuemei Cui, Jinyu Sun, Yuli Wang, Weishuang Li, Jianguo Fang*, 8-Aminoquinoline-based ratiometric zinc probe: Unexpected binding mode and its application in living cells, (Bioorganic & Medicinal Chemistry Letters, 2013, 23, 3511-3514).

13. Liangwei Zhang, Dongzhu Duan, Xuemei Cui, Jinyu Sun and Jianguo Fang*, A selective and sensitive fluorescence probe for imaging endogenous Zinc in living cells. (Tetrahedron, 2013, 69, 15-21).

14. Liangwei Zhang, Dongzhu Duan, Yaping Liu, Chunpo Ge, Xuemei Cui, Jinyu Sun, and Jianguo Fang*, Highly Selective Off-On Fluorescent Probe for Imaging Thioredoxin Reductase in Living Cells. (Journal of the American Chemical Society, 2014, 136, 226-233).

15. Dongzhu Duan, Baoxin Zhang, Juan Yao, Yaping Liu, Jinyu Sun, Chunpo Ge,Shoujiao Peng, Jianguo Fang, Gambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase. (Free Radical Biology and Medicine, 2014, 69, 15-25).

专利

1. 一种光动力理疗小分子及制备方法和使用方法（ZL 2022 1 0524969.3）。孙金玉;徐芷静;宋英壮。授权。

2. D-赖氨酸衍生物构筑的细菌细胞壁新生肽聚糖的生物发光检测体系及应用方法（ZL 2022 1 0525034.7）。孙金玉;宋英壮;徐芷静。授权。

3. 基于吖啶类衍生物的硼氮掺杂多环芳烃、合成方法及应用（ZL 202410587811X）。杨登涛,孙金玉,段溢,白凰鸣,郭嘉欣。公开。